Authorities seized 46 pounds of methamphetamine, 43 kilograms of cocaine, 4,120 pounds of marijuana, 20 guns and about $2.3 million in cash during the investigation.
Police in the United States have arrested 45 people they accuse of belonging to the Mexican drug cartel La Familia Michoacana.
Agents also seized cash, guns and drugs as part of their operation against the cell, based in Atlanta, Georgia.
Police said the city had become a major drug distribution centre, from where drugs were being shipped to neighbouring states.
But they said the arrests would disrupt the cartel's operation in Atlanta.
Operation Choke Hold began in May 2009 and targeted the Atlanta-area operations of La Familia Michoacana, authorities said at a news conference at a suburban Atlanta courthouse. Known as La Familia, it is one of Mexico's largest and most brutal cartels.
"It has been widely reported that the Atlanta metropolitan area has become a major distribution center for drug cartels based in Mexico," said Jack Killorin, director of the Atlanta High Intensity Drug Trafficking Area program. "Let today also document that law enforcement working together is successful in disrupting their operations."
Justice officials said those arrested would be charged with conspiracy to traffic drugs, money laundering and possession of firearms, among other things.
The agents said they seized more than 21 kg. of methamphetamine, 43kg of cocaine and more than 1870 kg of marijuana, 20 guns, six vehicles and almost $2.3 million dollars in cash. The drugs seized have a street value of over $10 million U.S. dollars.
Senior agent in the US Drug Enforcement Administration John Comer warned that while the operation to dismantle this particular cell had been successful, it was just one of many operating in the Atlanta area.
"Mexican cartels such as La Familia Michoacana have collectively become the most powerful drug trafficking organisations in the world, and have an impact on the United States," he said.
Sources: Reuters and AP